Jobbeschreibung
PhD Student (gn*) Life Sciences, Inflammation Research Fixed-term of 3 years | Part-time with 65% (25 hours/week) | Salary according to salary group 13 TV-L | The Department of Cardiology I - Coronary and Peripheral Vascular Disease | Job ID: 11189 We are at UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility. PROJECT TITLE: Reversing endotoxin tolerance using a trained immunity approach THE INSTITUTE AND PROJECT: The inflammation and immunimetablism group at the Molecular Cardiology lab led by Dr. Yahya Sohrabi focuses on studying underlying molecular and cellular mechanisms that regulate metabolism and epigenetic changes in the development of innate immune memory (trained immunity). The goal is to develop trained immunity approach against cardiometabolic diseases and its underlying such as sepsis. In collaboration with Prof. Mihai Netea and Dr Katarzyna Placek from the Life and Medical Sciences- Institute, University of Bonn, we investigate the mechanisms of the reversal of immune tolerance with the ultimate goal to improve patient treatment. The key feature of the project is to unveil unknown mechanistic details which are then translated towards innovative preclinical intervention strategies to reverse immune tolerance. Our group is highly interdisciplinary, international, and uses state-of-the-art techniques spanning a broad range from immunology, cell and molecular biology, omics and bioinformatics. The project is funded by the Deutsche Forschungsgemeinschaft ( DFG). Your Tasks Design and conduct experiments utilizing state-of-the-art approaches such as: In vitro and ex vivo cell culture, working with different types of primary and stable cells, and maybe creating knockout or knock in CRISPR/cas9 Basic and multiomics data analysis, Flow cytometric analysis of immune cell populations Immunohistological staining and imaging Biochemical assays for cytokines and other inflammatory mediators Protein analysis Collaborate closely with colleagues across disciplines to integrate findings into a comprehensive model of atherosclerosis pathophysiology Analyze data, interpret results, and present conclusions through high-quality publications, presentations, and reports Contribute to manuscript preparation Participate actively in departmental seminars, workshops, and conference What we expect: MSc or comparable degree in biological/ medical sciences Strong background in immunology/molecular biology Expertise in one or more of the following areas: Flow cytometry-based phenotyping and sorting Immunofluorescence microscopy and histopathological evaluation Statistical programming languages like R or Python Good communication skills in English; proficiency in German desirable but not required Willingness to work independently while contributing effectively to collaborative projects Willingness to participate in ongoing training programs to enhance expertise and stay up to date with latest methodologies What we offer: Comprehensive benefits package including health insurance, pension plan, and family support services Access to infrastructure , equipment, and resources Opportunities for professional growth, networking, and international collaboration Supportive environment fostering your own ideas, innovation, and interdisciplinary exchange For inquiries, please contact: Yahya Sohrabi,
[email protected] Apply now until October 15, 2025 and include Cover letter highlighting relevant experience, interests, and career goals (max. 2 pages) Curriculum Vvitae with publication list and academic record Contact details for two referees familiar with your scientific achievements BENEFITS Exciting Projects Professional Development and Training Interdisciplinary Collaboration Part of Research Innovation Additional Benefits Exciting Projects Professional Development and Training Interdisciplinary Collaboration Part of Research Innovation Additional Benefits (*gn=gender neutral) The University Hospital of Münster is one of the leading hospitals in Germany. Such a position cannot be achieved by size and medical successes alone. The individual commitment counts above all. We need your commitment so that even with little things we can achieve great things for our patients. There are many possibilities open for you so that you may develop with them. Universitätsklinikum Münster Albert-Schweitzer-Campus 1, Gebäude D5 48149 Münster www.ukm.de
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