Jobbeschreibung
The University Hospital Bonn (UKB) is a maximum care hospital with more than 1,300 beds. Our more than 9,000 employees take on tasks in research, teaching and patient care as well as in public health at the highest level. In the science ranking (LOMV) and in the economic result, the UKB is number 1 of the university hospitals in NRW and in 2021 had the third highest case mix index of the university hospitals in Germany.
The following position (E13; 65%) is to be filled as soon as possible and is for a period of three years at the Institute of Biochemistry and Molecular Biology of the University Hospital Bonn:
PhD student (m/f/d)
Mitochondria fulfil various essential functions for the survival of eukaryotic cells. Their biogenesis and functions depend on the import of more than 1000 different proteins that are produced as precursors on cytosolic ribosomes. Impaired mitochondrial targeting or defective import into mitochondria result in cytosolic accumulation of such proteins, causing proteotoxic stress. As a result, mitochondrial proteins aggregate in different cellular compartments, a hallmark of neurodegenerative diseases. Our biochemical and proteomic studies identified partner proteins of protein translocases acting in guiding proteins to mitochondria or their removal when import fails (Opalinski et al., 2018; Schulte et al., 2023 Nature; Mårtensson et al., 2019 Nature). We will study the molecular mechanisms of targeting and quality control of mitochondrial precursor proteins.
We use highly innovative techniques in biochemistry, molecular and cell biology. This includes robot based genetic screens combined with fluorescent imaging and protein-protein-interaction studies coupled with proteomic assays. We study the functionality and fate of proteins using protein stability, aggregation, disaggregation assays and analyse the state of post-trans-lational modifications with ubiquitin-family proteins. Moreover, we reconstitute the import and assembly of mitochondrial proteins synthesized in cell-free systems into intact organelles in vitro. We offer a well-equipped workspace in an active international team. The University of Bonn provides an excellent scientific research environment.
The position starts as soon as possible and is for a period of three years, with the possibility of an extension.
The ideal candidate will be a highly motivated, team-oriented graduate with a strong interest in protein biochemistry, molecular and cell biology. Experience with biochemical, cell and molecular biology techniques or proteomics is advantageous. Candidates should hold a diploma or a master's degree in Biology, Biochemistry, Molecular Medicine, Chemistry or a related subject.
- Responsible and versatile: a job with a lot of creative freedom in a collegial team
- Secure in the future: fee according to TV-L (E13; 65%)
- Flexible for families: flexible working time models, the option of a place in the company day-care center and offers for those returning from parental leave
- Provision for later: company pension scheme
- Clever to work: Possibility of an interest-free loan to buy an e-bike
- Tailor-made education: Subsidized further education and training
- Systematic start: Structured induction
- Healthy at work: Numerous health promotion offers, free membership in UKBfit
- Employer benefits: preferential offers for employees (corporate benefits)
We are committed to diversity and equal opportunities. Our goal is to increase the proportion of women in areas where women are underrepresented and to particularly promote their careers. We therefore urge relevantly qualified women to apply. Applications are treated in accordance with the State Equal Opportunities Act. Applications from suitable people with proven severe disabilities and those of equal status are particularly welcome.
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