Job Description
PhD Student (gn*) Biology, Molecular/Experimental Medicine, Biochemistry or related Fixed-term for 3 years | Part-time with 65% | Salary according to TV-L E 13 | Clinic for Vascular and Endovascular Surgery - Laboratory for Vascular Biology | Job ID: 11239 We are UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility. To meet our high standards every day, we are looking forward to your scientific expertise in the Laboratory for Vascular Biology at the Clinic for Vascular and Endovascular Surgery - ideally with you on board! We are seeking a motivated PhD candidate to join our research team investigating the role of gut microbiota-derived metabolites in cellular signaling processes, with a particular focus on aortic pathologies and endothelial integrity. PROJECT: This project aims to uncover how microbiota-derived metabolites influence the endothelial barrier function and neutrophil transmigration, with an emphasis on their implications in aortic disease development and progression. A key component of the project will also explore general metabolite-mediated signaling in the aortic endothelium, aiming to identify novel molecular pathways involved in vascular inflammation and remodeling. Your Tasks Analysis of human aortic tissue specimens Execution of in vitro experiments using primary human aortic endothelial cells Investigation of molecular mechanisms regulating endothelial barrier function and immune cell transmigration Collaborative work with core facilities for genomics and proteomics to generate and analyze large-scale datasets Identification and characterization of novel microbiota-metabolite-driven signaling pathways relevant to aortic endothelial function What we expect: Commitment to work in a multidisciplinary setting Motivated, independent, and collaborative way of working Master’s degree in biology, molecular/experimental medicine, biochemistry, or related Strong interest in vascular biology, immunology, and/or microbiota research Strong methodological background with experience in cell culture (static and flow conditions), microscopy and molecular biology techniques (Western Blot, (RT) qPCR, cloning etc.) What we offer: Motivated and supportive working group Committed mentoring Access to cutting-edge technologies and core facilities in genomics, proteomics, and bioinformatics Research laboratory with state-of-the art equipment Innovative technologies Excellent possibilities for career development Active participation in conferences For inquiries, please contact: Dr. Thorsten Eierhoff,
[email protected] Apply now via our career portal until 15.10.2025 including: Motivation letter (1 Page) CV Relevant certificates Reference letter (welcome) BENEFITS Exciting Projects Professional Development and Training Interdisciplinary Collaboration Part of Research Innovation Additional Benefits Exciting Projects Professional Development and Training Interdisciplinary Collaboration Part of Research Innovation Additional Benefits (*gn=gender neutral) The University Hospital of Münster is one of the leading hospitals in Germany. Such a position cannot be achieved by size and medical successes alone. The individual commitment counts above all. We need your commitment so that even with little things we can achieve great things for our patients. There are many possibilities open for you so that you may develop with them. Universitätsklinikum Münster Albert-Schweitzer-Campus 1, Gebäude D5 48149 Münster www.ukm.de
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