Job Description
The Fraunhofer-Gesellschaft currently operates 76 institutes and research units throughout Germany and is a leading applied research organization. Around 32 000 employees work with an annual research budget of 3.4 billion euros.
This postdoctoral position is part of a collaborative project between the Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Goethe University's Medical Campus, and the biopharmaceutical company Sanofi. Together, we aim to develop organoid models to combat inflammatory bowel diseases. The position will be based in Frankfurt am Main.
- Use primary cells from biopsy samples to develop patient-derived organoid models for inflammatory bowel diseases
- Develop complex co-culture systems combining patient-derived organoids and autologous immune cells to recreate human intestinal inflammation
- Establish a novel pharmacological platform for preclinical drug evaluation
- Evaluate disease trajectory and predictive potential through comparative spatial transcriptomic and single-cell analysis of organoid models and patient biopsy samples
- PhD in biology, biochemistry, molecular biology, cell biology, immunology, or a related discipline
- Experience with stem cell-derived organoid culture, as well as profound knowledge and hands-on experience with molecular, cell biology, and immunology techniques
- Advantageous but not required: Expertise in single-cell analysis technology, 3D high-throughput imaging, or patient biosample processing
- Ability to solve problems independently and to design/execute systematic data-driven experiments in a multidisciplinary and international team of scientists
- Excellent written and oral communication skills in English; additional German skills are a plus
- A multidisciplinary project with a strong focus on applied science
- Close collaboration with clinical researchers and a pharmaceutical industry partner
- Opportunities to present and publish your findings
- High degree of independence and autonomy
- Support for continuing education and further qualification